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Do not stop using Celexa without first talking to your doctor. For the treatment of depression. You must wait at least 14 days before you start taking an antidepressant, especially if you are younger than twenty years old. Ssri medications affect the levels of serotonin in the brain. Ssri medications affect the levels of serotonin in the brain, Celexa may cause relatively few and mild side effects, which tend to go away with continued treatment. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped.